Kinetin Riboside
Kinetin Riboside
CAS: 4338-47-0
Molecular Formula: C15H17N5O5
Kinetin Riboside - Names and Identifiers
Kinetin Riboside - Physico-chemical Properties
| Molecular Formula | C15H17N5O5 |
| Molar Mass | 347.33 |
| Density | 1.78±0.1 g/cm3(Predicted) |
| Melting Point | 152-154 °C |
| Boling Point | 683.7±65.0 °C(Predicted) |
| Solubility | DMSO (Slightly), Ethanol (Slightly, Heated, Sonicated), Methanol (Very Slightly, |
| Appearance | Solid |
| Color | White to Pale Brown |
| pKa | 13.11±0.70(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Hygroscopic |
| In vitro study | Kinetin riboside displays antiproliferative and apoptogenic activity against various human cancer cell lines. Kinetin riboside is able to inhibit the proliferation in HCT-15 human colon cancer cells in a dose-dependent manner (IC 50 =2.5 μM). Kinetin riboside induces apoptosis in HeLa and mouse melanoma B16F-10 cells. Kinetin riboside disrupts the mitochondrial membrane potential and induces the release of cytochrome c and activation of caspase-3. Bad are up-regulated while Bcl-2 is down-regulated under kinetin riboside exposure. |
| In vivo study | Kinetin riboside significantly suppresses tumor growth. The most effective anti-melanoma response is elicited at 40 mg/kg. |
Kinetin Riboside - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | AU7400200 |
| HS Code | 29349990 |
Kinetin Riboside - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.879 ml | 14.396 ml | 28.791 ml |
| 5 mM | 0.576 ml | 2.879 ml | 5.758 ml |
| 10 mM | 0.288 ml | 1.44 ml | 2.879 ml |
| 5 mM | 0.058 ml | 0.288 ml | 0.576 ml |
Last Update：2024-01-02 23:10:35
Kinetin Riboside - Reference Information
| overview | kinetic nucleoside can be used as an intermediate in pharmaceutical synthesis, such as preparing a new nucleoside RNA polymerase inhibitor in preparing a drug for treating enterovirus 71(EV71) infection. If you inhale dynamic nucleoside, please move the patient to fresh air; if the skin is in contact, you should remove the contaminated clothes, rinse the skin thoroughly with soapy water and water, and see a doctor if you feel uncomfortable; if you are in contact with clear eyes, you should separate the eyelids, Rinse with flowing water or normal saline, and see a doctor immediately; if you eat, rinse your mouth immediately, prohibit vomiting, and see a doctor immediately. |
| biological activity | Kinetin riboside are cytokinin analogs that can induce cancer cell death. The IC50 value of inhibiting HCT-15 cell proliferation was 2.5 μM. |
| target | IC50: 2.5 μM (HCT-15 cells) |
| in vitro study | Kinetin riboside displays antiproliferative and apoptogenic activity against various human cancer cell lines. Kinetin riboside is able to inhibit the proliferation in HCT-15 human colon cancer cells in a pose-dependent manner (IC 50=2.5 μ m). Kinetin riboside induces apoptosis in HeLa and mouse melanoma B16F-10 cells. Kinetin riboside disrupts the mitochondrial membrane potential and induces the release of cytochrome C and activation of caspase-3. Bad are up-regulated while Bcl-2 is down-regulated under kinetin riboside exposure. |
| in vivo study | Kinetin riboside significantly suppresses tumor growth. The most effective anti-melanoma response is elicited at 40 mg/kg. |
Last Update：2024-04-09 20:49:11
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